The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses

Abstract excerpt

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the activation of the transcription factors STAT3 and STAT6, but it is unclear how these events impact infection. Here, parasites that inject Cre-recombinase with rhoptry proteins were used to distinguish infected macrophages from those only injected with parasite proteins. Transcriptional profiling revealed that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytomegalovirus and herpesvirus research
• Share to Parasitic Infections and Diagnostics
• Share to Toxoplasma gondii Research Studies