Back to search

Article

Translocation of dense granule effectors across the parasitophorous vacuole membrane in <i>Toxoplasma</i> -infected cells requires the activity of ROP17, a rhoptry protein kinase

2019-04-18

Abstract excerpt

Toxoplasma gondii tachyzoites co-opt host cell functions through introduction of a large set of rhoptry- and dense granule-derived effector proteins. These effectors reach the host cytosol through different means: direct injection for rhoptry effectors and translocation across the parasitophorous vacuolar membrane (PVM) for dense granule (GRA) effectors. The machinery that translocates these GRA effectors has rece...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6483d3d3-09f4-57d3-816e-b7b322f991de
DOI
10.1101/613208
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Translocation of dense granule effectors across the parasitophorous vacuole membrane in <i>Toxoplasma</i> -infected cells requires the activity of ROP17, a rhoptry protein kinaseDOI 10.1101/613208
Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma- Infected Cells Requires the Activity of ROP17, a Rhoptry Protein KinaseSemantic proximity
The <i>Toxoplasma gondii</i> Dense Granule Protein GRA7 Is Phosphorylated upon Invasion and Forms an Unexpected Association with the Rhoptry Proteins ROP2 and ROP4Semantic proximity
Toxoplasma Effectors Targeting Host Signaling and TranscriptionSemantic proximity
The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence ofToxoplasma gondiiSemantic proximity
The<i>Toxoplasma gondii</i>rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7Semantic proximity
Biogenesis and discharge of the rhoptries: Key organelles for entry and hijack of host cells by the ApicomplexaSemantic proximity
Inverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membraneSemantic proximity
Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host CellsSemantic proximity
Secreted protein kinases regulate cyst burden during chronic toxoplasmosisSemantic proximity
Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondiiSemantic proximity
The secreted acid phosphatase domain-containing GRA44 from <i>Toxoplasma gondii</i> is required for C-myc induction in infected cellsSemantic proximity
Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.Semantic proximity
Select a neighboring publication to make it the new centre.