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Article

The<i>Toxoplasma gondii</i>rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7

6 Aug 2015

Abstract excerpt

In mice, avirulent strains (e.g. types II and III) of the protozoan parasite Toxoplasma gondii are restricted by the immunity-related GTPase (IRG) resistance system. Loading of IRG proteins onto the parasitophorous vacuolar membrane (PVM) is required for vacuolar rupture resulting in parasite clearance. In virulent strain (e.g. type I) infections, polymorphic effector proteins ROP5 and ROP18 cooperate to...

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PMID: 26247512
DOI: 10.1111/cmi.12499

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