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Secreted protein kinases regulate cyst burden during chronic toxoplasmosis

23 Jul 2016

Abstract excerpt

Toxoplasma gondii is an apicomplexan parasite that secretes a large number of protein kinases and pseudokinases from its rhoptry organelles. Although some rhoptry kinases (ROPKs) act as virulence factors, many remain uncharacterized. In this study, predicted ROPKs were assessed for bradyzoite expression then prioritized for a reverse genetic analysis in the type II strain Pru that is amenable to targeted...

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PMID: 27450947
DOI: 10.1111/cmi.12651

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