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Article

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011

Behnke Michael S, Khan Asis, Wootton John C, Dubey Jitender P, Tang Keliang, Sibley L David

Abstract excerpt

The population structure of Toxoplasma gondii includes three highly prevalent clonal lineages referred to as types I, II, and III, which differ greatly in virulence in the mouse model. Previous studies have implicated a family of serine/threonine protein kinases found in rhoptries (ROPs) as important in mediating virulence differences between strain types. Here, we explored the genetic basis of differences in...

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Identifiers

PMID: 21586633
DOI: 10.1073/pnas.1015338108
PMCID: PMC3111276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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