Article
ATF6β is a host cellular target of the <i>Toxoplasma gondii</i> virulence factor ROP18
13 Jun 2011
Abstract excerpt
The ROP18 kinase has been identified as a key virulence determinant conferring a high mortality phenotype characteristic of type I Toxoplasma gondii strains. This major effector molecule is secreted by the rhoptries into the host cells during invasion; however, the molecular mechanisms by which this kinase exerts its pathogenic action remain poorly understood. In this study, we show that ROP18 targets the host...
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