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Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction

7 Dec 2022

Abstract excerpt

Toxoplasma gondii is an intracellular parasite that can infect many host species and is a cause of significant human morbidity worldwide. T. gondii secretes a diverse array of effector proteins into the host cell which are critical for infection. The vast majority of these secreted proteins have no predicted functional domains and remain uncharacterised. Here, we carried out a pooled CRISPR knockout screen in the...

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PMID: 36476844
DOI: 10.1371/journal.ppat.1011021

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