Article

Collateral Responses to Classical Cytotoxic Chemotherapies are Heterogeneous and Sensitivities are Sparse

2021-04-15

Abstract excerpt

Chemotherapy resistance is a major obstacle to curing cancer patients. Combination drug regimens have shown promise as a method to overcome resistance; however, to date only some cancers have been cured with this method. Collateral sensitivity – the phenomenon whereby resistance to one drug is co-occurrent with sensitivity to a second drug – has been gaining traction as a promising new concept to guide rational de...

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Literature Corpus work: d3f41f88-e9fd-523f-aa0a-6a6cd33e6342
DOI: 10.1101/2021.04.15.440042

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