Back to search

Article

Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewing’s sarcoma

2020-02-12

Abstract excerpt

<h4>Summary</h4> Advances in the treatment of Ewing’s sarcoma (EWS) are desperately needed, particularly in the case of metastatic disease. A deeper understanding of collateral sensitivity, where the evolution of therapeutic resistance to one drug aligns with sensitivity to another drug, may improve our ability to effectively target this disease. For the first time in a solid tumor, we produced a temporal collate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
888bbc77-ef45-578d-9da7-743a107f632a
DOI
10.1101/2020.02.11.943936
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewing’s sarcomaDOI 10.1101/2020.02.11.943936
Leveraging Experimental Evolution to Extract Predictive Collateral Drug Response Signatures in Ewings SarcomaSemantic proximity
Collateral sensitivities with predictive signatures emerge in a novel model of evolved chemoresistance in osteosarcomaSemantic proximity
Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancerSemantic proximity
Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancerSemantic proximity
The landscape of drug sensitivity and resistance in sarcomaSemantic proximity
The landscape of drug sensitivity and resistance in sarcomaSemantic proximity
Molecular characterization informs prognosis in patients with localized Ewing sarcoma: A report from the Children’s Oncology GroupSemantic proximity
Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional AdaptationSemantic proximity
Collateral Responses to Classical Cytotoxic Chemotherapies are Heterogeneous and Sensitivities are SparseSemantic proximity
Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanomaSemantic proximity
Drug resistance in recurrent and metastatic Ewing sarcomaSemantic proximity
PGAP6 drives chemotherapy resistance in Ewing sarcomaSemantic proximity
Select a neighboring publication to make it the new centre.