Article

Collateral sensitivities with predictive signatures emerge in a novel model of evolved chemoresistance in osteosarcoma

2026-08-11

Abstract excerpt

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite aggressive multimodal therapy, including surgery and chemotherapy with methotrexate, doxorubicin, and cisplatin (MAP), outcomes for patients with relapsed or refractory disease remain poor, with no standardized second-line regimen. We developed a clinically calibrated, temporally resolved in vitro model to exami...

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Literature Corpus work: f9c15ad1-848a-5798-a858-63deb46f2137
DOI: 10.64898/2026.08.10.743977

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