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Leveraging Experimental Evolution to Extract Predictive Collateral Drug Response Signatures in Ewings Sarcoma

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Therapeutic options for patients with relapsed or refractory Ewings sarcoma (EWS) remain limited. Collateral sensitivity, where resistance to one drug confers sensitivity to another, could be leveraged to optimize chemotherapy for EWS. Gene expression signatures that predict collateral sensitivity states can be used to guide treatment selection in an evolution-informed manner. We experimentally...

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Literature Corpus work
b50870aa-9c3f-56d9-9053-fd9bdfc62626
DOI
10.1101/2025.09.19.677399
Open publication

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Leveraging Experimental Evolution to Extract Predictive Collateral Drug Response Signatures in Ewings SarcomaDOI 10.1101/2025.09.19.677399
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