Article

CHMP2B regulates TDP-43 phosphorylation and proteotoxicity via modulating CK1 turnover independent of the autophagy-lysosomal pathway

2020-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Protein inclusions containing phosphorylated TDP-43 are a shared pathology in several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, most ALS/FTD patients do not have a mutation in TDP-43 or the enzymes directly regulating its phosphorylation. It is intriguing how TDP-43 becomes hyperphosphorylated in each disease condition. I...

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Literature Corpus work: d3ecc5a2-31ad-5f0e-b4df-99c4d7c58da3
DOI: 10.1101/2020.06.04.133546

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