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Article

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.

The Journal of biological chemistry - 14 Dec 2012

Tashiro Yoshitaka, Urushitani Makoto, Inoue Haruhisa, Koike Masato, Uchiyama Yasuo, Komatsu Masaaki, Tanaka Keiji, Yamazaki Maya, Abe Manabu, Misawa Hidemi, Sakimura Kenji, Ito Hidefumi, Takahashi Ryosuke

Abstract excerpt

Evidence suggests that protein misfolding is crucially involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, controversy still exists regarding the involvement of proteasomes or autophagy in ALS due to previous conflicting results. Here, we show that impairment of the ubiquitin-proteasome system, but not the autophagy-lysosome system in motor neurons replicates ALS in mice. Conditional...

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Identifiers

PMID: 23095749
DOI: 10.1074/jbc.M112.417600
PMCID: PMC3522293

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FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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