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Article

Lessons learned from CHMP2B, implications for frontotemporal dementia and amyotrophic lateral sclerosis.

Neurobiology of disease - 1 Jan 2021

Ugbode Chris, West Ryan J H

Abstract excerpt

Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two neurodegenerative diseases with clinical, genetic and pathological overlap. As such, they are commonly regarded as a single spectrum disorder, with pure FTD and pure ALS representing distinct ends of a continuum. Dysfunctional endo-lysosomal and autophagic trafficking, leading to impaired proteostasis is common across the FTD-ALS...

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Identifiers

PMID: 33144171
DOI: 10.1016/j.nbd.2020.105144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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