Article
A cellular model of TDP-43 induces phosphorylated TDP-43 aggregation with distinct changes in solubility and autophagy dysregulation.
The FEBS journal - 1 Sept 2025
Dopler Matthew B, Abeer Muhammad I, Arezoumandan Sanaz, Cox Keyshawn, Petersen Tyler L, Daniel Esther H, Cannon Carlton L, Bautista Angelica, Blancher Kennedy D, Bland Alysia M, Bond Kylie J, Davis Dominque A, Francois Jessica M, McCray Eliana J, Morgan Justin M, Pulliam Jessica L, Robinson Zymir A, Taylor Mykia J, Dowell James A, Cairns Nigel J, Gitcho Michael A
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that affects neurons in the brain and spinal cord, causing loss of muscle control, and eventually leads to death. Phosphorylated transactive response DNA binding protein-43 (TDP-43) is the major pathological protein in both sporadic and familial ALS, forming cytoplasmic aggregates in over 95% of cases. Of the 10-15% of ALS cases that...
Topics
Join the communities discussing this publication.