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Article

Molecular Neuropathology of TDP-43 Proteinopathies

9 Jan 2009

Abstract excerpt

The identification of TDP-43 as the major component of the pathologic inclusions in most forms of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS) resolved a long-standing enigma concerning the nature of the ubiquitinated disease protein under these conditions. Anti-TDP-43 immunohistochemistry and the recent development of...

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PMID: 19333444
DOI: 10.3390/ijms10010232

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