Article

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

2024-10-01

Abstract excerpt

TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in iPSC line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers of TDP-43 levels in neurons. A meta-analysis of our screen and publicly available screens identified both specific hits...

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Literature Corpus work: 9c7fd236-32c2-591d-9298-847347f00bf0
DOI: 10.1101/2024.09.30.615241

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