Article

CK1δ/e-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis

2024-11-08

Abstract excerpt

<title>Abstract</title> <p>Hyperphosphorylated TDP-43 aggregates in the cytoplasm of motor neurons is a neuropathological signature of amyotrophic lateral sclerosis (ALS). These aggregates have been proposed to possess a toxic disease driving role in ALS pathogenesis and progression, however, the contribution of phosphorylation to TDP-43 aggregation and ALS disease mechanisms remains poorly understood. We’ve prev...

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Literature Corpus work: 3feb4022-c188-5a77-968e-9f2619eb0e7c
DOI: 10.21203/rs.3.rs-5334588/v1

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