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Article

Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies

9 Sept 2022

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which motor neurons in spinal cord and motor cortex are progressively lost. About 15% cases of ALS also develop the frontotemporal dementia (FTD), in which the frontotemporal lobar degeneration (FTLD) occurs in the frontal and temporal lobes of the brain. Among the pathologic commonalities in ALS and FTD is ubiquitin-positive cytoplasmic...

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PMID: 36158183
DOI: 10.3389/fcell.2022.931968

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