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Article

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

Molecular cell - 21 Oct 2011

Matsumoto Gen, Wada Koji, Okuno Misako, Kurosawa Masaru, Nukina Nobuyuki

Abstract excerpt

Selective macroautophagy (autophagy) of ubiquitinated protein is implicated as a compensatory mechanism of the ubiquitin-proteasome system. p62/SQSTM1 is a key molecule managing autophagic clearance of polyubiquitinated proteins. However, little is known about mechanisms controlling autophagic degradation of polyubiquitinated proteins. Here, we show that the specific phosphorylation of p62 at serine 403 (S403) in...

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Identifiers

PMID: 22017874
DOI: 10.1016/j.molcel.2011.07.039

Genes

SQSTM1

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