Article

<i>Atm</i> loss does not radiosensitize a primary mouse model of <i>Pten</i> -deleted brainstem glioma

2022-08-05

Abstract excerpt

Diffuse midline gliomas arise in the brainstem and other midline brain structures and cause a large proportion of childhood brain tumor deaths. Radiation therapy is the most effective treatment option, but these tumors ultimately progress. Inhibition of the phosphoinositide-3-kinase (PI3K)-like kinase ataxia telangiectasia mutated (ATM), which orchestrates the cellular response to radiation-induced DNA damage, may...

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Literature Corpus work: 8db0283d-fe48-5ca9-8b42-f8dd7662e471
DOI: 10.1101/2022.08.05.502656

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