Article

FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

2023-03-05

Abstract excerpt

<h4>SUMMARY</h4> Insulin inhibits gluconeogenesis and stimulates glucose conversion to glycogen and lipids. How these activities are coordinated to prevent hypoglycemia and hepatosteatosis is not clear. Fructose-1,6 bisphosphatase (FBP1) is rate controlling for gluconeogenesis. However, inborn human FBP1 deficiency does not cause hypoglycemia unless accompanied by fasting or starvation, which also trigger paradox...

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Literature Corpus work: d3bd667f-c731-5a56-b819-0bfc8139bc21
DOI: 10.1101/2023.03.05.531181

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