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Article

Activating AKT2 mutation: hypoinsulinemic hypoketotic hypoglycemia.

The Journal of clinical endocrinology and metabolism - 1 Feb 2014

Arya Ved Bhushan, Flanagan Sarah E, Schober Edith, Rami-Merhar Birgit, Ellard Sian, Hussain Khalid

Abstract excerpt

BACKGROUND: Hyperinsulinemic hypoglycemia (HH), characterized by unregulated insulin secretion, is an important cause of persistent and severe hypoglycemia. The biochemical picture of HH is hypoketotic hypo-fatty-acidemic hypoglycemia along with elevated serum insulin. Not infrequently, serum insulin might be undetectable in HH despite the presence of evidence of insulin action (suppressed ketogenesis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24285683
DOI: 10.1210/jc.2013-3228

Genes

AKT2
ABCC8
GLUD1
KCNJ11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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