Hoofbeats, zebras, and insights into insulin resistance.

Abstract excerpt

In this issue of the JCI, Semple and colleagues report phenotypic evaluation of patients with a germline mutation in the gene encoding serine/threonine kinase AKT2 (see the related article beginning on page 315). Their findings support the idea that the postreceptor actions of insulin in the liver--suppression of gluconeogenesis and stimulation of lipogenesis--are mediated through divergent pathways that can be...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to AKT2 gene
• Share to Insulin Resistance
• Share to Mutation