Article

Specific Pathogen Free Ten Gene-Edited Pig Donor for Xenotransplantation

2025-05-10

Abstract excerpt

Xenotransplantation has entered the clinical phase to fulfill the global organ shortage. However, recent clinical studies revealed that the xenograft from current gene-edited (GE) pigs still poses the risk of immune rejection, and biosafety concerns. In this study, we successfully constructed a large batch of 10- (GTKO/CMAHKO/ β4GalNT2KO/hCD46/hCD55/hCD59/hTBM/hEPCR/hCD39/hCD47) GE cloned (GEC) donor pigs by utili...

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Literature Corpus work: d187308d-acbe-5ede-b6b9-e41fd74fa622
DOI: 10.1101/2025.05.06.652168

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