Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation

Abstract excerpt

For many patients with chronic organ failure, transplantation is the only therapeutic option, but the number of donated human organs and tissues falls far short of the need. Porcine cells, tissues, and organs likely will be an alternative transplant source, since pigs can be genetically engineered to overcome rejection mechanisms and physiological incompatibilities, and to reduce the risk of transmitting zoonotic...

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