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A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model

10 Jun 2022

Abstract excerpt

Pig-to-human organ transplantation is a feasible solution to resolve the shortage of organ donors for patients that wait for transplantation. To overcome immunological rejection, which is the main hurdle in pig-to-human xenotransplantation, various engineered transgenic pigs have been developed. Ablation of xeno-reactive antigens, especially the 1,3-Gal epitope (GalT), which causes hyperacute rejection, and...

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PMID: 35688851
DOI: 10.1038/s41598-022-13536-z

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