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Evaluation of Physiological Integrity in Six‐Gene‐Edited Bama Miniature Pigs as a Model for Xenotransplantation

1 May 2025

Abstract excerpt

Genetically engineered pigs exhibit significant potential as a solution to organ scarcity in xenotransplantation. Nonetheless, a formidable challenge lies in overcoming the rejection of porcine organs by the human immune system. In this study, we generated a six-gene-edited pig model by simultaneously knocking out three major xenoantigens, GGTA1, CMAH, and β4GalNT2, along with the incorporation of coagulation...

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PMID: 40371941
DOI: 10.1002/biot.70030

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