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Reduced <i>PIN1</i> gene expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypes

2023-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Women have a higher incidence of Alzheimer’s disease (AD), even after adjusting for increased longevity. Thus, there is an urgent need to identify the molecular networks that underpin the sex-associated risk of AD. Recent efforts have identified PIN1 as a key regulator of tau phosphorylation signaling pathway . Pin1 is the only gene, to date, that when deleted can cause both tau and Aβ-related...

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Literature Corpus work
d3a4b1f4-0119-5b89-8708-220227036bfb
DOI
10.1101/2023.08.14.553279
Open publication

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Reduced <i>PIN1</i> gene expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypesDOI 10.1101/2023.08.14.553279
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