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Article

Reduced PIN1 expression in neocortical and limbic brain regions in female Alzheimer's patients correlates with cognitive and neuropathological phenotypes.

Neurobiology of aging - 1 Sept 2024

de Ávila Camila, Suazo Crystal, Nolz Jennifer, Nicholas Cochran J, Wang Qi, Velazquez Ramon, Dammer Eric, Readhead Benjamin, Mastroeni Diego

Abstract excerpt

Women have a higher incidence of Alzheimer's disease (AD), even after adjusting for increased longevity. Thus, there is an urgent need to identify genes that underpin sex-associated risk of AD. PIN1 is a key regulator of the tau phosphorylation signaling pathway; however, potential differences in PIN1 expression, in males and females, are still unknown. We analyzed brain transcriptomic datasets focusing on sex...

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PMID: 38964013
DOI: 10.1016/j.neurobiolaging.2024.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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