Article

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

2022-12-02

Abstract excerpt

Somatic cell reprogramming and oncogenic transformation share surprisingly similar features, yet transformed cells are highly resistant to reprogramming. There must be barriers that block transformed cells from reprogramming, but the nature of those barriers is unclear. In this study, we generated a systematic panel of transformed mouse embryonic fibroblasts (MEFs) using a variety of oncogenic transgenes, and disc...

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Literature Corpus work: a3cb9b45-e7ec-5b07-9630-b5ab4a8acc2c
DOI: 10.1101/2022.12.01.518778

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