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Cellular reprogramming – lowering gravity on Waddington's epigenetic landscape

1 Jan 2012

Abstract excerpt

During development, cell fate is specified precisely through programming by multiple complex elements and processes, including chromatin modifications that result in epigenetic marks. Once determined, cell fate is specified further only through maturation processes, which include differentiation and senescence. However, recent studies have shown that it is possible to influence cell fate through artificial...

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PMID: 22736045
DOI: 10.1242/jcs.084822

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