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Article

Loss of Fic causes progressive neurodegeneration in a Drosophila model of hereditary spastic paraplegia

8 Jul 2024

Abstract excerpt

Hereditary Spastic Paraplegia (HSP) is a group of rare inherited disorders characterized by progressive weakness and spasticity of the legs. Recent newly discovered biallelic variants in the gene FICD were found in patients with a highly similar phenotype to early onset HSP. FICD encodes filamentation induced by cAMP domain protein. FICD is involved in the AMPylation and deAMPylation protein modifications of the...

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PMID: 38986817
DOI: 10.1016/j.bbadis.2024.167348

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