Article

Parkinson’s-linked LRRK2-G2019S derails AMPAR trafficking, mobility and composition in striatum with cell-type and subunit specificity

2023-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s (PD) is a multi-factorial disease that affects multiple brain systems and circuits. While defined by motor symptoms caused by degeneration of brainstem dopamine neurons, debilitating non-motor abnormalities in fronto-striatal based cognitive function are common, appear early and are initially independent of dopamine. Young adult mice expressing the PD-associated G2019S missense mutat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12c0b931-5797-59e8-9070-bb4885241c02
DOI: 10.1101/2023.10.13.562231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Parkinson’s-linked LRRK2-G2019S derails AMPAR trafficking, mobility and composition in striatum with cell-type and subunit specificityDOI 10.1101/2023.10.13.562231Read

Pathway-specific deregulation of striatal excitatory synapses in LRRK2 mutationsSemantic proximity Read

Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutationsSemantic proximity Read

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s diseaseSemantic proximity Read

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease.Semantic proximity Read

LRRK2 at the pre‐synaptic site: A 16‐years perspectiveSemantic proximity Read

LRRK2 G2019S disrupts GABAergic signaling and shifts excitatory/inhibitory balance in the striatumSemantic proximity Read

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursorsSemantic proximity Read

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in miceSemantic proximity Read

Parkinson’s disease-linked Parkin mutations impair glutamatergic synaptic transmission and plasticitySemantic proximity Read

Endosomal Traffic And Glutamate Synapse Activity Are Increased In VPS35 D620N Mutant Knock-In Mouse Neurons, And Resistant To LRRK2 Kinase InhibitionSemantic proximity Read

Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's diseaseSemantic proximity Read

Disease-associated mutations in GluK2 disrupt compartment-specific regulatory mechanisms controlling kainate receptor membrane traffickingSemantic proximity Read