Article

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease

2021-08-05

Abstract excerpt

The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80 % of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is finely regulated by endocytic events, recycling to the plasma membrane and degradation. Noteworthy, deficits in EAAT2 have been associated with neuronal excitotoxicity and neurodegeneration. In this study, we show that EAAT2 trafficking is im...

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Literature Corpus work: 739a1c4f-d575-5ad3-a512-28b9d17c4dee
DOI: 10.1101/2021.08.04.455053

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