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Article

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease.

Acta neuropathologica - 1 Jul 2022

Iovino Ludovica, Giusti Veronica, Pischedda Francesca, Giusto Elena, Plotegher Nicoletta, Marte Antonella, Battisti Ilaria, Di Iacovo Angela, Marku Algerta, Piccoli Giovanni, Bandopadhyay Rina, Perego Carla, Bonifacino Tiziana, Bonanno Giambattista, Roseti Cristina, Bossi Elena, Arrigoni Giorgio, Bubacco Luigi, Greggio Elisa, Hilfiker Sabine, Civiero Laura

Abstract excerpt

The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is finely regulated by endocytic events, recycling to the plasma membrane and degradation. Noteworthy, deficits in EAAT2 have been associated with neuronal excitotoxicity and neurodegeneration. In this study, we show that EAAT2 trafficking is...

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Identifiers

PMID: 35596783
DOI: 10.1007/s00401-022-02437-0
PMCID: PMC9217889

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