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Article

Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations

2 Oct 2020

Abstract excerpt

LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input in Parkinson's disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these mutations alter the structure and function of individual synapses on direct and indirect pathway SPNs is unknown and may reveal pre-clinical changes in dopamine-recipient neurons that predispose...

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PMID: 33006315
DOI: 10.7554/elife.58997

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