Article

Potential glutamatergic and GABAergic false neurotransmitters in models of excitation-inhibition imbalance

2026-05-04

Abstract excerpt

<title>Abstract</title> <p> We previously determined that 2-Methylglutamate (2MeGlu) and 4-aminopentanoic acid (4APA) have neurochemical properties of glutamatergic and GABAergic false neurotransmitters (FNTs); here, we tested whether their activity impacts mouse models with excitation-inhibition (E-I) imbalance. We first screened racemic agents using models caused by E-I imbalance; rac-2MeGlu, but not rac-4APA,...

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Literature Corpus work: dc711791-4adf-5ef9-8d13-424c1e38e33d
DOI: 10.21203/rs.3.rs-8875573/v1

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