Aneuploidy effects on human gene expression across three cell types

Abstract excerpt

Aneuploidy syndromes impact multiple organ systems but understanding of tissue-specific aneuploidy effects remains limited—especially for the comparison between peripheral tissues and relatively inaccessible tissues like brain. Here, we address this gap in knowledge by studying the transcriptomic effects of chromosome X, Y, and 21 aneuploidies in lymphoblastoid cell lines, fibroblasts and iPSC-derived neuronal...

Topics

Join the communities discussing this publication.

• Chromatin Remodeling and Cancer
• Genomic variations and chromosomal abnormalities
• Prenatal Screening and Diagnostics