Article

The somatically generated T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

2017-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor β chains and variou...

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Literature Corpus work: d33e707a-d957-56b8-9b70-a25d70d5bd8d
DOI: 10.1101/176388

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