Dynamics of positive and negative selection in the thymus: review and hypothesis.

doi:10.1016/0165-2478(90)90040-w

Back to search

Article

Dynamics of positive and negative selection in the thymus: review and hypothesis.

Immunology letters - 1 Jun 1990

Marusić-Galesić S, Pavelić K

Abstract excerpt

T cells recognize with a single receptor both a product of antigens processed by antigen presenting cells (APC1) and a self-marker molecule, encoded by the major histocompatibility complex (MHC, a property termed MHC-restricted recognition of antigen). During their differentiation in the thymus,...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
Cell Differentiation
Female
Histocompatibility Antigens
Immune Tolerance
Male
Mice
Mice, Transgenic
Models, Biological
Phenotype
Receptors, Antigen, T-Cell
Selection, Genetic
T-Lymphocytes
Thymus Gland

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.