Article
Affinity maturation of lymphocyte receptors and positive selection of T cells in the thymus.
Immunological reviews - 1 Oct 1993
Steele E J, Rothenfluh H S, Ada G L, Blanden R V
Abstract excerpt
In this review we have re-evaluated the dominant paradigm that TcR V genes do not somatically mutate. We highlight the many structural and functional similarities between Ig and TcR antigen-specific receptors on B and T cells. We have reviewed the factors influencing the somatic and germline evol...
Topics
- Animals
- Humans
- Models, Biological
- Mutation
- Receptors, Antigen, B-Cell
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- Thymus Gland