Article
The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.
eLife - 17 Nov 2017
Marrack Philippa, Krovi Sai Harsha, Silberman Daniel, White Janice, Kushnir Eleanor, Nakayama Maki, Crooks James, Danhorn Thomas, Leach Sonia, Anselment Randy, Scott-Browne James, Gapin Laurent, Kappler John
Abstract excerpt
Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor β chains and various MHC alleles, we...
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