Article
Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells.
European journal of immunology - 1 Oct 1990
Jacobs H, Von Boehmer H, Melief C J, Berns A
Abstract excerpt
In several transgenic mouse models T cell development was shown to be controlled by the binding of the alpha/beta T cell receptor (TcR) to ligands in the thymus. In transgenic mice expressing a male-specific TcR alpha/beta, the presence of the restricting D major histocompatibility complex (MHC)...
Topics
- Animals
- Antibodies, Monoclonal
- Binding Sites
- Crosses, Genetic
- Female
- Flow Cytometry
- H-Y Antigen
- Histocompatibility Antigens Class I
- Immunophenotyping
- Lymphocyte Activation
- Male
- Mice
- Mice, Transgenic
- Mutation
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Sex Characteristics
- Spleen