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Article

Regulatory T cells and co-evolution of allele-specific MHC recognition by the TCR.

Scandinavian journal of immunology - 1 Mar 2020

Steele Edward J, Lindley Robyn A

Abstract excerpt

What is the evolutionary mechanism for the TCR-MHC-conserved interaction? We extend Dembic's model (Dembic Z. In, Scand J Immunol e12806, 2019) of thymus positive selection for high-avidity anti-self-MHC Tregs among double (CD4 + CD8+)-positive (DP) developing thymocytes. This model is based on competition for self-MHC (+ Pep) complexes presented on cortical epithelium. Such T cells exit as...

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Identifiers

PMID: 31793005
DOI: 10.1111/sji.12853
PMCID: PMC7064991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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