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An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung Cancer

2026-07-01

Abstract excerpt

<title>Abstract</title> <p> Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC), yet the majority of patients eventually experience resistance. The tumor microenvironment (TME), particularly the myeloid compartment, orchestrates immune evasion. However, the spatial and functional interplay between specific macrophage subpopulations and exhausted...

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Literature Corpus work
d32aeac0-b67f-5527-954e-32e9b7a77365
DOI
10.21203/rs.3.rs-10202716/v1
Open publication

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An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung CancerDOI 10.21203/rs.3.rs-10202716/v1
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