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PSMB5-centered immunotherapy resistance signature predicts prognosis and drives CD8+ T cell exclusion in lung adenocarcinoma

2026-08-18

Abstract excerpt

<h4>Background</h4> Immune checkpoint inhibitors (ICIs) achieve limited response rates in lung adenocarcinoma (LUAD), and the mechanisms underlying immunotherapy resistance remain poorly understood. Robust predictive biomarkers are urgently needed. <h4>Methods</h4> We integrated single-cell transcriptomic data, multi-cohort bulk RNA-seq datasets, and spatial transcriptomics to systematically identify an immunoth...

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Literature Corpus work
b40ceeea-57cc-5f88-8c10-83178b7c2e9d
DOI
10.64898/2026.08.16.26360303
Open publication

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PSMB5-centered immunotherapy resistance signature predicts prognosis and drives CD8+ T cell exclusion in lung adenocarcinomaDOI 10.64898/2026.08.16.26360303
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