Back to search

Article

NFKBID Links SPP1⁺ Tumor-Associated Macrophages to CD8⁺ T-Cell Exhaustion and Immunotherapy Response in Lung Adenocarcinoma

2026-06-18

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> T-cell exhaustion (Tex) and tumor-associated macrophages (TAMs) profoundly shape the immunosuppressive tumor microenvironment (TME) in lung adenocarcinoma (LUAD). However, the upstream macrophage-derived signals and transcriptional regulators driving CD8⁺ T-cell dysfunction remain poorly defined. This study aimed to delineate the macrophage–T-cell axis and ide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b76e3aba-cf48-5f2a-b7ef-6cd77b8c418b
DOI
10.21203/rs.3.rs-9531556/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
NFKBID Links SPP1⁺ Tumor-Associated Macrophages to CD8⁺ T-Cell Exhaustion and Immunotherapy Response in Lung AdenocarcinomaDOI 10.21203/rs.3.rs-9531556/v1
Dissecting T Cell Exhaustion in Non-Small Cell Lung Cancer: Single-Cell and Spatial Transcriptomics Reveal Prognostic Signatures and Therapeutic ImplicationsSemantic proximity
Integrative single-cell analysis of LUAD: elucidating immune cell dynamics and prognostic modeling based on exhausted CD8+ T cellsSemantic proximity
An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung CancerSemantic proximity
Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modelingSemantic proximity
A machining learning-based prognostic model integrating multi-omics defines LGMN as a lysosomal checkpoint on macrophages with co- expressed myeloid checkpoints TIM-3 and LILRB4 associated with immunotherapy resistance in NSCLCSemantic proximity
Multi-Omics reveals SPP1+ Malignant and CXCR4+ TAM crosstalk predicts immunotherapy response in lung adenocarcinoma cancerSemantic proximity
Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung AdenocarcinomaSemantic proximity
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.Semantic proximity
Identification of T-cell exhaustion-related genes and prediction of their immunotherapeutic role in lung adenocarcinomaSemantic proximity
Single-cell and spatial landscapes reveal coordinated CD8+ T-cell programs defining responder-specific immune niches in NSCLCSemantic proximity
Transcriptional states of lung cancer microenvironment reveal macrophage subtype dynamics linked to disease progressionSemantic proximity
Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinomaSemantic proximity
Select a neighboring publication to make it the new centre.