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Article

Coordinated Multicellular Immune Programs and Drug Targets Revealed by Single-Cell Analysis in Driver-Mutated NSCLC.

International journal of molecular sciences - 29 Apr 2026

Yang Kuan, Yang Kaiyue, Wang Jiasi, Zhao Hang, Jiang Wenqi, Mu Depeng, Peng Xiao, Yan Yiming, Gao Xing, Bai Jing, Hu Congxue, Zhang Yunpeng, Li Xia

Abstract excerpt

Oncogenic driver mutations in non-small cell lung cancer (NSCLC) activate defined signaling pathways that sustain tumor growth and influence the immune landscape. Yet, how coordinated interactions among diverse cell populations within the tumor immune microenvironment (TIME) contribute to this process remains largely unresolved. To address this, we profiled approximately 200,000 single cells from 45...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42123577
DOI: 10.3390/ijms27093997
PMCID: PMC13163347

Genes

EGFR
KRAS
MET
MIF
PSAP
PTN
RETN
ROS1
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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