Article

RIOK2 drives glioblastoma cell proliferation by modulating MYC through the RNA-binding protein IMP3

2020-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is the most common primary malignant brain tumor and is resistant to current therapies. Here, using a combination of proteomic and genetic approaches in both Drosophila and human GBM models, we identify novel signaling effectors that act downstream of EGFR and PI3K signaling pathways, which drive GBM. Our results indicate that RIOK2, an atypical serine/threonine kinase, forms...

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Literature Corpus work: d30a2f12-b299-5b1a-8b9d-d4ea72fcd81a
DOI: 10.1101/2020.12.07.413385

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